The E60 M5 was introduced in 2005, with an uneven firing V10 engine and 7 speed sequential manual gear box linking the car with the BMW Sauber Formula One program.[2] The E60 M5 was the world’s first production sedan to feature a V10 petrol engine.

The E60 uses an odd firing V10 which has won multiple World Engine of the Year awards, S85 engine produces 373 kW (507 PS; 500 bhp) and 520 N·m (380 lb·ft) of torque. The engine and transmission were designed from scratch for this particular model; they are not based on other models.